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Pfizer for Oncology Professionals - Oncology News

Oncology News features editorially independent news content provided by MDLinx. Pfizer does not influence and is not involved with the selection of content in this section.

  • Subtype and pathway specific responses to anticancer compounds in breast cancer
    Heiser LM et al. Collections of breast cancer cell lines mirror many of the molecular subtypes and..
    Thu, 23 Feb 2012

  • Defibrotide for prophylaxis of hepatic veno-occlusive disease in pediatric hemopoietic stem-cell transplantation: An open-label, phase 3, randomized controlled trial
    Corbacioglu S et al. Defibrotide prophylaxis seems to reduce incidence of veno-occlusive disease a..
    Thu, 23 Feb 2012

  • Long-term assessment of quality of life in the Intergroup Exemestane Study: 5 years post-randomization
    Fallowfield LJ et al. Clinical benefits of switching to exemestane are accompanied by good overal..
    Thu, 23 Feb 2012

  • Prognostic role of PIK3CA mutation in colorectal cancer: Cohort study and literature review
    Liao X et al. Co-existence of PIK3CA (the PI3K p110alpha subunit) exon 9 and 20 mutations, but ..
    Thu, 23 Feb 2012

  • Prognostic significance of chromosome 3 alterations determined by microsatellite analysis in uveal melanoma: A long-term follow-up study
    Thomas S et al. This study shows that large tumors with disomy 3 have an increased risk to develop..
    Thu, 23 Feb 2012

  • Connexin 47 mutations increase risk for secondary lymphedema following breast cancer treatment
    Finegold D et al. The findings challenge the view that secondary lymphedema is solely due to mechan..
    Thu, 23 Feb 2012

  • A randomised trial of primary tamoxifen versus mastectomy plus adjuvant tamoxifen in fit elderly women with invasive breast carcinoma of high oestrogen receptor content
    Johnston SJ et al. Irrespective of the degree of oestrogen receptor (ER) positivity, surgery achiev..
    Thu, 23 Feb 2012

  • Clinical correlates of BRCAness in triple-negative breast cancer of patients receiving adjuvant chemotherapy
    Oonk AMM et al. BRCA1like tumors share clinical features, like young age at diagnosis and similar n..
    Thu, 23 Feb 2012

  • Phase IB study of the EpCAM antibody adecatumumab combined with docetaxel in patients with EpCAM-positive relapsed or refractory advanced-stage breast cancer
    Schmidt M et al. Combination therapy of adecatumumab and docetaxel is safe, feasible, and potential..
    Thu, 23 Feb 2012

  • Expression profiling of cancerous and normal breast tissues identifies microRNAs that are differentially expressed in serum from patients with (metastatic) breast cancer and healthy volunteers
    van Schooneveld E et al. The study provides a basis for the establishment of miRNAs as biomarkers f..
    Thu, 23 Feb 2012

  • Comorbidity in elderly cancer patients in relation to overall and cancer-specific mortality
    J rgensen TL et al. Colorectal and lung cancer was associated with increased comorbidity burden i..
    Thu, 23 Feb 2012

  • Microsatellite instability and Beta2-Microglobulin mutations as prognostic markers in colon cancer
    Tikidzhieva A et al. The risk of late disease relapse was significantly lower in patients with high..
    Thu, 23 Feb 2012

  • An epigenetic role for PRL-3 as a regulator of H3K9 methylation in colorectal cancer
    Liu Y et al. The data reveal a new role for PRL3 as a key regulator of histone demethylation. JMJD1..
    Thu, 23 Feb 2012

  • Adherence to Stage-Specific Treatment Guidelines for Patients With Colon Cancer
    Chagpar R et al. Among patients with highrisk stage II or stage III disease, older patients with pr..
    Thu, 23 Feb 2012

  • Phase III study of nilotinib versus best supportive care with or without a TKI in patients with gastrointestinal stromal tumors resistant to or intolerant of imatinib and sunitinib
    Reichardt P et al. In the intenttotreat (ITT) analysis, no significant difference in progressionfre..
    Thu, 23 Feb 2012

  • Imatinib rechallenge in patients with advanced gastrointestinal stromal tumors
    Blay JY et al. Discontinuation of imatinib in responding patients with advanced gastrointestinal st..
    Thu, 23 Feb 2012

  • Effect of Tumor Load on Energy Expenditure in Patients With Pancreatic Cancer
    Vaisman N et al. Pancreatic cancer does not increase resting energy expenditure (REE) above the nor..
    Thu, 23 Feb 2012

  • JAK/STAT signal pathway activation promotes progression and survival of human oesophageal squamous cell carcinoma
    You Z et al. The results provide convincing evidence for the first time that the JAK/STAT pathway m..
    Thu, 23 Feb 2012

  • Current Management and Future Strategies of Gastric Cancer
    Lee JH et al. To improve prognosis and quality of life in gastric cancer patients, both standardiza..
    Thu, 23 Feb 2012

  • Smoking behavior and exposure to tobacco toxicants during 6 months of smoking progressively reduced nicotine content cigarettes
    Benowitz NL et al. These data support the proposition that the intake of nicotine from cigarette..
    Thu, 23 Feb 2012

  • First-line chemotherapy with liposomal doxorubicin plus cisplatin for patients with advanced malignant pleural mesothelioma
    Arrieta O et al. The combination of liposomal doxorubicin (LD) and cisplatin results in an active t..
    Thu, 23 Feb 2012

  • Percutaneous Cryoablation of Lung Tumors: Feasibility and Safety
    Inoue M et al. Percutaneous cryoablation could be performed minimally invasively with acceptable ra..
    Thu, 23 Feb 2012

  • The interrelationships between Src, Cav-1 and RhoGD12 in transitional cell carcinoma of the bladder
    Qayyum T et al. The results demonstrate that in contrast to other solid tumours, activation of the ..
    Thu, 23 Feb 2012

  • Increased expression of NuSAP in recurrent prostate cancer is mediated by E2F1
    Gulzar ZG et al. NuSAP is a novel biomarker for prostate cancer recurrence after surgery and its ov..
    Thu, 23 Feb 2012

  • Immunohistochemical marker panel differentiates between the three most common subtypes of renal cell carcinoma independent from histomorphologic criteria
    Walter B et al. The panel can reliably recognize two main renal cell carcinoma (RCC) subtypes witho..
    Thu, 23 Feb 2012

  • Circulating tumour cells in prostate cancer patients receiving salvage radiotherapy
    Lowes LE et al. The results demonstrate that circulating tumour cells (CTCs) can be detected in ear..
    Thu, 23 Feb 2012

  • Docetaxel with or without estramustine for estramustine refractory castration-resistant prostate cancer: a single institution experience
    Nakano K et al. Although treatment with docetaxel (DTX) at 60 mg/m2 was effective and highly tolera..
    Thu, 23 Feb 2012

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