Guide Patient Expectations When Administering SUTENT

Remind patients to disclose any other medications they are taking

• Including vitamins, herbal products, and over-the-counter remedies, which can interact with SUTENT in different ways
• Strong CYP3A4 inducers and inhibitors can affect the metabolism and plasma concentrations of SUTENT

Remind patients to talk to you immediately about their adverse reactions (ARs)

• Early intervention and management of ARs (eg, diarrhea, fatigue, and hypertension) may help to keep patients on SUTENT^1,2

Remind patients to take advantage of resources that may help support their information needs between office visits

• Refer patients to SUTENT.com and the Patient Call Center

Dose Adjustments for CYP3A4 Inhibitors or Inducers

Strong CYP3A4 inhibitors and inducers should be avoided as they can affect the metabolism and plasma concentrations of SUTENT, and they may have an effect on efficacy and tolerability.

When SUTENT Must Be Coadministered With…

A Strong CYP3A4 Inhibitor, for example…

SUTENT Dose Reduction Should Be Considered

In 12.5-mg increments (to a minimum of 37.5 mg), and clinical response and tolerability should be carefully monitored.

• Patients should not eat grapefruit or drink grapefruit juice while taking SUTENT

When SUTENT Must Be Coadministered With…

A Strong CYP3A4 Inducer, for example…

SUTENT Dose Increase Should Be Considered

In 12.5-mg increments (to a maximum of 87.5 mg), and clinical response and tolerability should be carefully monitored.

• Patients should not take St. John's Wort while taking SUTENT