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A. For Intramuscular Administration
When oral therapy is not feasible and the strength, dosage form, and route of administration
of the drug reasonably lend the preparation to the treatment of the condition, the
intramuscular use of DEPO-MEDROL Sterile Aqueous Suspension is indicated as follows:
1. Endocrine Disorders
Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is
the drug of choice; synthetic analogs may be used in conjunction with mineralocorticoids
where applicable; in infancy, mineralocorticoid supplementation is of particular
importance)
Acute adrenocortical insufficiency (hydrocortisone or cortisone is the drug of choice;
mineralocorticoid supplementation may be necessary, particularly when synthetic
analogs are used)
Preoperatively and in the event of serious trauma or illness, in patients with known
adrenal insufficiency or when adrenocortical reserve is doubtful:
- Congenital adrenal hyperplasia
- Hypercalcemia associated with cancer
- Nonsuppurative thyroiditis
2. Rheumatic Disorders
As adjunctive therapy for short-term administration (to tide the patient over an
acute episode or exacerbation) in:
- Post-traumatic osteoarthritis
- Epicondylitis
- Synovitis of osteoarthritis
- Acute nonspecific tenosynovitis
- Rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may
require low-dose maintenance therapy)
- Acute gouty arthritis
- Psoriatic arthritis
- Ankylosing spondylitis
- Acute and subacute bursitis
3. Collagen Diseases
During an exacerbation or as maintenance therapy in selected cases of:
- Systemic lupus erythematosus
- Acute rheumatic carditis
- Systemic dermatomyositis (polymyositis)
4. Dermatologic Diseases
- Pemphigus
- Bullous dermatitis herpetiformis
- Severe erythema multiforme (Stevens-Johnson syndrome)
- Severe seborrheic dermatitis
- Severe psoriasis
- Exfoliative dermatitis
- Mycosis fungoides
5. Allergic States
Control of severe or incapacitating allergic conditions intractable to adequate
trials of conventional treatment in:
- Bronchial asthma
- Drug hypersensitivity reactions
- Contact dermatitis
- Urticarial transfusion reactions
- Atopic dermatitis
- Acute noninfectious laryngeal edema (epinephrine is the drug of first choice)
- Serum sickness
- Seasonal or perennial allergic rhinitis
6. Ophthalmic Diseases
Severe acute and chronic allergic and inflammatory processes involving the eye,
such as:
- Herpes zoster ophthalmicus
- Sympathetic ophthalmia
- Iritis, iridocyclitis
- Anterior segment inflammation
- Chorioretinitis
- Allergic conjunctivitis
- Diffuse posterior uveitis and choroiditis
- Allergic corneal marginal ulcers
- Optic neuritis
- Keratitis
7. Gastrointestinal Diseases
To tide the patient over a critical period of the disease in:
- Ulcerative colitis (systemic therapy)
- Regional enteritis (systemic therapy)
8. Respiratory Diseases
- Symptomatic sarcoidosis
- Loeffler's syndrome not manageable by other means
- Berylliosis
- Fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate
antituberculous chemotherapy
- Aspiration pneumonitis
9. Hematologic Disorders
- Acquired (autoimmune) hemolytic anemia
- Erythroblastopenia (RBC anemia)
- Secondary thrombocytopenia in adults
- Congenital (erythroid) hypoplastic anemia
10. Neoplastic Diseases
For palliative management of:
- Leukemias and lymphomas in adults
- Acute leukemia of childhood
11. Edematous States
To induce diuresis or remission of proteinuria in the nephrotic syndrome, without
uremia, of the idiopathic type or that due to lupus erythematosus
12. Nervous System
Acute exacerbations of multiple sclerosis
13. Miscellaneous
- Tuberculous meningitis with subarachnoid block or impending block when used concurrently
with appropriate antituberculous chemotherapy
- Trichinosis with neurologic or myocardial involvement
B. For Intrasynovial Or Soft Tissue Administration
DEPO-MEDROL is indicated as adjunctive therapy for short-term administration (to
tide the patient over an acute episode or exacerbation) in:
- Synovitis of osteoarthritis
- Epicondylitis
- Rheumatoid arthritis
- Acute nonspecific tenosynovitis
- Acute and subacute bursitis
- Post-traumatic osteoarthritis
- Acute gouty arthritis
C. For Intralesional Administration
DEPO-MEDROL is indicated for intralesional use in the following conditions:
- Keloids
- Localized hypertrophic, infiltrated, inflammatory lesions of:
- Lichen planus, psoriatic plaques, granuloma annulare, and lichen simplex chronicus
(neurodermatitis)
- Discoid lupus erythematosus
- Necrobiosis lipoidica diabeticorum
- Alopecia areata
DEPO-MEDROL also may be useful in cystic tumors of an aponeurosis or tendon (ganglia).
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