Important Safety Information and Indication
  • BeneFix, Coagulation Factor IX (Recombinant), is contraindicated in patients who have manifested life-threatening, immediate hypersensitivity reactions, including anaphylaxis, to the product or its components, including hamster protein.
  • Hypersensitivity reactions, including anaphylaxis, have been reported with BeneFix. Closely monitor patients for signs and symptoms of acute anaphylaxis, particularly during the early phases of initial exposure to the product. Immediately discontinue the administration of the product and initiate appropriate treatment if symptoms occur.
  • Patients may develop hypersensitivity to hamster (CHO) protein as BeneFix contains trace amounts.
  • BeneFix has been associated with the development of thromboembolic complications, including patients receiving continuous infusion through a central venous catheter. The safety and efficacy of BeneFix administration by continuous infusion have not been established.
  • Neutralizing antibodies (inhibitors) have been reported following the administration of BeneFix. If expected plasma factor IX activity levels are not attained, or if the patient presents with an allergic reaction, or if bleeding is not controlled following an expected dose of BeneFix, perform an assay that measures factor IX inhibitor concentration.
  • The most common adverse reactions (>5%) from clinical trials were nausea, injection site reaction, injection site pain, headache, dizziness and rash.


BeneFix, Coagulation Factor IX (Recombinant), is a human blood coagulation factor indicated in adult and pediatric patients with hemophilia B (congenital factor IX deficiency or Christmas disease) for the control and prevention of bleeding episodes and peri-operative management.

Limitations of use:

BeneFix is NOT indicated for:

  • treatment of other factor deficiencies (eg, factors II, VII, VIII and X),
  • treatment of hemophilia A patients with inhibitors to factor VIII,
  • reversal of coumarin-induced anticoagulation,
  • treatment of bleeding due to low levels of liver-dependent coagulation factors.

Please see Full Prescribing Information for BeneFix

Financial Support

Pfizer Factor Savings Card—Your eligible patients can save up to $12,000 on BeneFix

Factor Savings Card,* the first line of support for current factor patients, is the easiest way to start saving now. Eligible patients can save $12,000 annually in 4 simple steps. This savings card can be used to help cover copay, deductible, and coinsurance costs associated with Pfizer factor products.

Getting started: Enroll online:

1. Find out if your patient is eligible

Direct your patient to visit our resources and support page on to answer a few questions and determine eligibility.

2. Fill out the registration form

If your patient is eligible, he or she will get access to an online registration form to fill in his or her information.

3. Download the card

Once the registration has been completed, the Factor Savings Card can be downloaded and printed out.

4. Keep the card and use it

Your patient may use the card when filling his or her prescription for every purchase until the maximum benefit of $12,000 has been reached or the card has expired, whichever comes first.

Factor Savings Card

Click image to download card.

To request cards, please contact your representative, call 1-888-240-9040, or

*This card will be accepted only at participating pharmacies. This coupon is not health insurance.

Terms and Conditions apply.

If you have questions about the use of the Pfizer Factor Savings Card, please call 1-888-240-9040 or send questions to: Pfizer Factor Savings Program, 6501 Weston Parkway, Suite 370, Cary, NC 27513. The Factor Savings Card cannot be combined with other offers and is limited to one person. You may also visit our resources and support page on for more information.

Download a compressive guide on financial support from Pfizer Hemophilia.

OFFER TERMS: By using the Pfizer Factor Savings Card, you acknowledge that you currently meet the eligibility criteria and will comply with the terms and conditions described below:

The Card is not valid for prescriptions that are eligible to be reimbursed, in whole or in part, by Medicaid, Medicare or any other federal or state healthcare programs (including any state prescription drug assistance programs and the Government Health Insurance Plan, available in Puerto Rico, formerly known as “La Reforma de Salud”). The Card is not valid for prescriptions that are eligible to be reimbursed by private insurance plans or other health or pharmacy benefit programs which reimburse you for the entire cost of your prescription drugs. You will receive a total benefit of $12,000 over 12 months, or the amount of your co-pay over 12 months less a patient financial responsibility of $10 per month, whichever is less. You must deduct the value of this offer from any reimbursement requests submitted to your insurance plan either by you or on your behalf. The Card is not valid where otherwise prohibited by law. The Card cannot be combined with any other rebate/coupon, free trial, or similar offer for the specified prescription. The card will be accepted only at participating pharmacies. This coupon is not health insurance. Offer good only in the U.S. and Puerto Rico. The Card is limited to 1 per person during this offering period and is not transferable. Offer limited to one use per month up to 12 times per patient per year. Pfizer reserves the right to rescind, revoke, or amend this offer without notice. Offer expires 12/31/16. No membership fees.


Pfizer RxPathways—Reimbursement support services and patient assistance program

Pfizer RxPathways® is a comprehensive assistance program that provides eligible patients (insured, uninsured, and underinsured) with a range of support services.

Benefits for eligible patients may include:
  • Insurance counseling and assistance in locating alternative funding, if needed
  • Pfizer RxPathways copay assistance for privately insured patients up to $10,000 through the calendar year
  • Free medicine for patients without insurance or patients with insurance who do not have coverage for the Pfizer factor product or cannot afford their copay
  • A Pfizer RxPathways savings card for uninsured patients who do not qualify for free medicine

Getting started: How to enroll

1. Check eligibility

Direct your patient to visit Pfizer RxPathways and select the medicine(s) he or she has been prescribed to see which Pfizer RxPathways services are available. By answering a few questions online, your patient can find out which services may be available to him or her.

2. View results and apply

Finally, your patient can download and complete the applications for the programs for which he or she is eligible, or you may download the appropriate application for your patient and complete it together.

Enrolling assistance

If patients require immediate assistance, they or their prescribers can call 1.877.744.5675, Monday through Friday, 8:00 AM – 6:00 PM ET.

Contact us

Have additional questions? Call 1.877.744.5675 or visit Pfizer RxPathways to learn more about how Pfizer RxPathways can help.

Download a compressive guide on financial support from Pfizer Hemophilia.

Pfizer RxPathways is a joint program of Pfizer Inc and the Pfizer Patient Assistance Foundation.

*BeneFix was approved February 11, 1997.1


*BeneFix was approved February 11, 1997.1