OHR was defined as MHR (CHR + no evidence of leukemia) or RCP. All responses were confirmed after 4 weeks. CHR for AP and BP CML: WBC count ≤ institutional ULN, platelets ≥100,000/mm3 and <450,000/mm3, ANC ≥1.0x109/L, no blasts or promyelocytes in peripheral blood, <5% myelocytes + metamyelocytes in bone marrow, <20% basophils in peripheral blood, and no extramedullary involvement. No evidence of leukemia: meets all other criteria for CHR except may have thrombocytopenia (platelets ≥20,000/mm3 and <100,000/mm3) and/or neutropenia (ANC ≥0.5x109/L and <1.0x109/L). RCP was defined as disappearance of features defining AP or BP but still in CP.1
AdvP=advanced phase; ANC=absolute neutrophil count; AP=accelerated phase; BP=blast phase; CHR=complete hematologic response; CI=confidence interval; CP=chronic phase; MCyR=major cytogenetic response; MHR=major hematologic response; OHR=overall hematologic response; RCP=return to chronic phase; TKI=tyrosine kinase inhibitor; ULN=upper limit of normal; WBC=white blood cell.