Dosing and administration

Convenient once-daily dosing1
BOSULIF is available in 400-, 500-, and 100-mg tablets
Tablets shown are not actual size.
*There are no clinical data for efficacy at the dose of 200 mg once daily in patients with CML.
Administration
Continue treatment with BOSULIF until disease progression or intolerance to therapy
If a dose is missed beyond 12 hours, the patient should skip the dose and take the usual prescribed dose on the following day
Dose escalation1
In clinical studies of adult Ph+ CML patients, dose escalation by increments of 100 mg once daily to a maximum of 600 mg once daily was allowed in patients who did not achieve or maintain a hematologic, cytogenetic, or molecular response and who did not have grade 3 or higher adverse reactions at the recommended starting dose
AP=accelerated phase; BP=blast phase; Ph+=Philadelphia chromosome–positive.
Reference
1.
BOSULIF Prescribing Information. New York, NY: Pfizer Inc.