Mechanism of Action

How CHANTIX® (varenicline) is believed to work
CHANTIX works in a way that is believed to help break the reward cycle of nicotine2,9
Based on animal models and in vitro studies. For illustrative purposes only.
The efficacy of CHANTIX in smoking cessation is believed to be the result of varenicline’s activity at the α4β2 subtype of the nicotine receptor, where its binding produces agonist activity while simultaneously preventing nicotine from binding to these receptors.2