Dosing

In adults with FM
Consider your next steps for LYRICA (pregabalin) titration, based on efficacy and tolerability

Dosage may be increased to 300 mg/day based on efficacy and tolerability
within 1 week

Patients may be titrated to 450 mg/day if they are not experiencing sufficient benefit
with 300 mg/day

When discontinuing LYRICA, taper gradually over a minimum of 1 week

Adjust the LYRICA daily dose based on renal function

For adult patients undergoing hemodialysis, adjust the pregabalin daily dose based on renal function. In addition to the daily dose adjustment, administer a supplemental dose immediately following every 4-hour hemodialysis treatment
Supplementary dosage following hemodialysis (mg)
  • Patients on the 25 mg QD regimen: take one supplemental dose of 25 mg or 50 mg
  • Patients on the 25-50 mg QD regimen: take one supplemental dose of 50 mg or 75 mg
  • Patients on the 50-75 mg QD regimen: take one supplemental dose of 75 mg or 100 mg
  • Patients on the 75 mg QD regimen: take one supplemental dose of 100 mg or 150 mg
The use of LYRICA in pediatric patients with compromised renal function has not been studied.
*Total daily dose (mg/day) should be divided as indicated by dose regimen to provide mg/dose.
Supplementary dose is a single additional dose.
Did you know?

of patients with FM are never titrated to the recommended therapeutic LYRICA dose1‡
Research based on de-identified electronic health records (EHR) of 50,194 patients with FM, gathered between August 2012 and July 2015.

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Titration to a therapeutic dose may lead to a greater adherence1

Based on a retrospective review of LYRICA prescriptions filled for FM, patients taking LYRICA titrated to a therapeutic dose had greater adherence after 12 months1

Data description

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Managing patient expectations before initiating treatment may help your patients get started and
STAY ON TRACK WITH LYRICA

Reference: 1. Data on file. Pfizer Inc, New York, NY.