Multi-indication Dosing

Recommended dosing information for LYRICA (pregabalin) across all approved indications

Consider your next steps for LYRICA titration, based on efficacy and tolerability

Click to expand complete dosing and titration guidance for each indication.

Dosage may be increased from 150 mg/day to 300 mg/day based on efficacy and tolerability within 1 week

  When discontinuing LYRICA, taper gradually over a minimum of 1 week 

Dosage may be increased from 150 mg/day to 300 mg/day based on efficacy and tolerability
 within 1 week

For patients who do not experience sufficient benefit with 300 mg/day, the dosage may be
 increased to 450 mg/day

   When discontinuing LYRICA, taper gradually over a minimum of 1 week 

Dosage may be increased from 150 mg/day to 300 mg/day based on efficacy and tolerability
 within 1 week

Patients who do not experience sufficient pain relief with 300 mg/day after 2 to 4 weeks of treatment and who are able to tolerate LYRICA may be
 titrated up to 600 mg/day

   When discontinuing LYRICA, taper gradually over a minimum of 1 week 

Dosage may be increased from 150 mg/day to 300 mg/day based on efficacy and tolerability
 within 1 week

Patients who do not experience sufficient pain relief with 300 mg/day after 2 to 3 weeks of treatment and who are able to tolerate LYRICA may be
 titrated up to 600 mg/day

   When discontinuing LYRICA, taper gradually over a minimum of 1 week 

Adjust the LYRICA daily dose based on renal function

Creatinine Clearance
(CLcr) (mL/min)

Total LYRICA Daily Dose
(mg/day)*

Dose Regimen

≥60

150

300

450

600

BID or TID
30-60

75

150

225

300

BID or TID
15-30

25-50

75

100-150

150

QD or BID
<15

25

25-50

50-75

75

QD

For patients undergoing hemodialysis, adjust the pregabalin daily dose based on renal function. In addition to the daily dose adjustment, administer a supplemental dose immediately following every 4-hour hemodialysis treatment

Supplementary dosage following hemodialysis (mg)

  • Patients on the 25 mg QD regimen: take one supplemental dose of 25 mg or 50 mg
  • Patients on the 25-50 mg QD regimen: take one supplemental dose of 50 mg or 75 mg
  • Patients on the 50-75 mg QD regimen: take one supplemental dose of 75 mg or 100 mg
  • Patients on the 75 mg QD regimen: take one supplemental dose of 100 mg or 150 mg

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