*Prilosec OTC contains the active ingredient omeprazole magnesium 20.6 mg, equivalent to omeprazole 20 mg used in this study.
†Acid control (pH >4) does not imply symptom relief. The correlation of pH data to clinical outcome has not been directly established.
‡Based on patients completing an overall treatment effect (OTE) questionnaire at week 2 to report if their upper abdominal pain and/or discomfort was improving or worsening using a 7-grade scale. For analysis, the OTE questionnaire was combined into a 15-point scale comprising the 7-point improvement scale, the status “about the same,” and the 7-point worsening scale.
§Nexium 24HR may take 1-4 days for full effect.
||Managed Markets Insight & Technology, LLC, database as of April 2016.
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References: 1. Lind T, Rydberg L, Kylebäck A, et al. Esomeprazole provides improved acid control vs. omeprazole in patients with symptoms of gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 2000;14(7):861-867. 2. Katz P, Kahrilas PJ, Johnson DA, et al. Daytime intragastric acid control: post hoc analyses of esomeprazole 20 mg and over-the-counter proton-pump inhibitors. Therap Adv Gastroenterol. 2015;8(6):322-330. 3. Wilder-Smith C, Lind T, Lundin C, Nauclér E, Nilsson-Pieschl C, Röhss K. Acid control with esomeprazole and lansoprazole: a comparative dose-response study. Scand J Gastroenterol. 2007;42(2):157-164. 4. Data on file. Pfizer Consumer Healthcare; 2015.