Dosing and Administration

Total infusion time for OCTAGAM 10% based on rate of infusion
A range of infusion rates, starting at 1 mg/kg/min up to a maximum of ≤12 mg/kg/min, as tolerated1
*The figure above is based on the ramp-up schedule for OCTAGAM 10% valid for a 70-kg patient receiving a 1 g/kg dose.1
  • It is recommended that OCTAGAM 10% be started at 1 mg/kg/min and can be dosed at the infusion rates shown below, if the previous rate is tolerated1*
Dosing and rate of administration1
Infusion rate increases (based on tolerability)1
  • 60% (54 of 90) patients achieved the maximum infusion rate allowed at 12 mg/kg/min in the cITP clinical study1
  • Monitor the patient carefully throughout the infusion1
    • Certain adverse drug reactions may be related to the rate of infusion
    • Slowing or stopping the infusion usually allows the symptoms to disappear promptly
    • Once the symptoms subside, the infusion may then be resumed at a lower rate
  • For patients at risk of renal dysfunction or thromboembolic events, administer OCTAGAM 10% at the minimum infusion rate practicable, not to exceed 3.3 mg/kg/min1
Preparation and handling of OCTAGAM 10%: DOs and DON’Ts1
DO visually inspect OCTAGAM 10% for particulate matter and discoloration before using (if the solution and container permit).1
DO use right away after the bottle has been entered or opened, and throw away partially used bottles. OCTAGAM 10% contains no preservatives—it is for single use only.1
DO pool the contents of OCTAGAM 10% bottles under aseptic conditions with sterile infusion bags and infuse within 8 hours after pooling.1
DO administer OCTAGAM 10% at room temperature, only by the IV route.1
DO select (if using) an in-line filter with a pore size of 0.2-200 microns. OCTAGAM 10% is not supplied with an infusion set.1
DO insert the needle only once within the delineated stopper area.1
DO penetrate the stopper perpendicular to its plane and within the ring.1
DON’T use if turbid and/or discolored.1
DON’T mix with other medicinal products.1
DON’T administer with other IV preparation in the same infusion set.1
DON’T mix with other IVIg products.1
DON’T freeze OCTAGAM 10%.1
DON’T use if OCTAGAM 10% is frozen.1
DON’T use after expiration date.1
DON’T dilute OCTAGAM 10%.1
DON’T use a needle larger than 16 gauge to prevent the possibility of coring.1
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REFERENCE
  1. OCTAGAM 10% [prescribing information]. Hoboken, NJ: Octapharma USA Inc.; 2018.