Burden of IPD

Clinical syndromes

There are 3 major clinical syndromes of IPD: meningitis, bacteremia, and bacteremic pneumonia1

The most common ways IPD can present in your practice include1:
Icons of a brain, droplet, and lungs
Bacteremic pneumonia accounts for 12%-16% of IPD in children ≤2 years of age1
  • Streptococcus pneumoniae is the most common cause of community-acquired cases of bacteremic pneumonia2
Bacteremic pneumonia can pose serious risks of complications in infants and younger children3
  • Bacteremic pneumonia can present clinically in children as severe respiratory distress requiring mechanical ventilation and can lead to respiratory failure, pleural effusions, pleural empyema, and meningitis3
Bacteremic pneumonia image
References:
  1. Centers for Disease Control and Prevention. Epidemiology and Prevention of Vaccine-Preventable Diseases. In: Hamborsky J, Kroger A, Wolfe S, eds. 13th ed. Washington, DC: Public Health Foundation; 2015:275-296.
  2. Fritz CQ, Edwards KM, Self WH, et al. Prevalence, risk factors, and outcomes of bacteremic pneumonia in children. Pediatrics. 2019;144(1):e20183090.
  3. Tan TQ. Pediatric invasive pneumococcal disease in the United States in the era of pneumococcal conjugate vaccines. Clin Microbiol Rev. 2012;25(3):409-419. doi:10.1128/CMR.00018-12.
References:
  1. Centers for Disease Control and Prevention. Epidemiology and Prevention of Vaccine-Preventable Diseases. In: Hamborsky J, Kroger A, Wolfe S, eds. 13th ed. Washington, DC: Public Health Foundation; 2015:275-296.
  2. Fritz CQ, Edwards KM, Self WH, et al. Prevalence, risk factors, and outcomes of bacteremic pneumonia in children. Pediatrics. 2019;144(1):e20183090.
  3. Tan TQ. Pediatric invasive pneumococcal disease in the United States in the era of pneumococcal conjugate vaccines. Clin Microbiol Rev. 2012;25(3):409-419. doi:10.1128/CMR.00018-12.