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XALATAN safety information
XALATAN® (latanoprost ophthalmic solution) is contraindicated in patients with known hypersensitivity to latanoprost, benzalkonium chloride, or any other ingredients in this product.
XALATAN may cause changes to pigmented tissues. Most frequently reported changes are increased pigmentation of the iris, periorbital tissue (eyelid), and eyelashes. Pigmentation is expected to increase as long as XALATAN is administered. Iris pigmentation is likely to be permanent. Eyelid skin darkening and eyelash changes may be reversible. The effects beyond 5 years are unknown.
XALATAN should be used with caution in patients with a history of intraocular inflammation (iritis/uveitis) and should generally not be used in patients with active intraocular inflammation.
XALATAN should be used with caution in aphakic patients, in pseudophakic patients with a torn posterior lens capsule, or in patients with known risk factors for macular edema.
XALATAN should be used with caution in patients with a history of herpetic keratitis.
There have been reports of bacterial keratitis associated with the use of multiple-dose containers of topical ophthalmic products.
The preservative in XALATAN, benzalkonium chloride, may be absorbed by contact lenses. Contact lenses should be removed prior to administration of XALATAN. Contact lenses should be reinserted 15 minutes following administration.
The most common reported adverse events (5%-15%) in XALATAN clinical trials included blurred vision, burning and stinging, conjunctival hyperemia, foreign-body sensation, itching, increased iris pigmentation, and punctate epithelial keratopathy.
The combined use of 2 or more prostaglandins or prostaglandin analogs, including XALATAN, is not recommended. It has been shown that administration of these prostaglandin drug products more than once daily may decrease the intraocular–pressure lowering effect or cause paradoxical elevations in IOP.
XALATAN is indicated for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension.
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